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Sie sind hier: Startseite Forschung Dr. D. Winter Publications

Publications

Journal Articles

2022

  • Jordans, S., Hardt, R., Becker, I., Winter, D., Wang-Eckhardt, L., Eckhardt, M. Age-Dependent Increase in Schmidt-Lanterman Incisures and a Cadm4-Associated Membrane Skeletal Complex in Fatty Acid 2-hydroxylase Deficient Mice: a Mouse Model of Spastic Paraplegia SPG35. Mol Neurobiol (2022). https://doi.org/10.1007/s12035-022-02832-4
  • Singh, J., Elhabashy, H., Muthukottiappan, P., Stepath, M., Eisenacher, M., Kohlbacher, O., Gieselmann, V., Winter, D. Cross-linking of the Endolysosomal System Reveals Flotillin Structures and Putative Cargo. bioRxiv. 2022.01.12.475930, https://doi.org/10.1101/2022.01.12.475930 - PREPRINT

2021

  • Winter, D., Becker, T. Surveying the mitochondrial proteome. Nat Cell Biol (2021). https://doi.org/10.1038/s41556-021-00801-y
  • Turan, F., Yilmaz, Ö., Schünemann, L., Lindenberg, T.T., Kalanithy, J.C., Harder, A., Ahmadi, S., Duman, T., MacDonald, R.B., Winter, D., Liu, C., Odermatt, B. Effect of modulating glutamate signaling on myelinating oligodendrocytes and their development—A study in the zebrafish model. J Neurosci Res. 2021; 00: 000– 000. https://doi.org/10.1002/jnr.24940
  • Muthukottiappana, P. and Winter, D. A proteomic view on lysosomes. Molecular Omics 2021. https://doi.org/10.1039/D1MO00205H
  • Mosen, P.R., Hardt, R. and Winter, D. (2021), RapiGest Precipitation Depends on Peptide Concentration. PROTEOMICS. Accepted Author Manuscript 2100129. https://doi.org/10.1002/pmic.202100129
  • Balboa, E., Marín, T., Oyarzún, J.E., Contreras, P.S., Hardt, R., van den Bosch, T., Alvarez, A.R., Rebolledo-Jaramillo, B., Klein, A.D.; Winter, D., Zanlungo, S. Proteomic Analysis of Niemann-Pick Type C Hepatocytes Reveals Potential Therapeutic Targets for Liver Damage. Cells 2021, 10, 2159. https://doi.org/10.3390/cells10082159
  • Di Lorenzo, G., Westermann, L.M., Yorgan, T.A., Stürznickel, J., Ludwig, N.F., Ammer, L.S., Baranowsky, A., Ahmadi, S., Pourbarkhordariesfandabadi, E., Breyer, S.R., Board, T.N., Foster, A. , Mercer, J., Tylee, K., Voltolini Velho, R., Schweizer, M., Renné, T., Braulke, T., Randon, D.N., Sperb-Ludwig, F., Lapagesse de Camargo Pinto, L., Araujo Moreno, C., Cavalcanti, D.P., Amling, M., Kutsche, K., Winter, D., Muschol, N.M., Schwartz, I.V.D, Rolvien, T., Danyukova, T., Schinke, T., Pohl, S. Pathogenic variants in GNPTAB and GNPTG encoding distinct subunits of GlcNAc-1-phosphotransferase differentially impact bone resorption in patients with mucolipidosis type II and III. Genet Med (2021). https://doi.org/10.1038/s41436-021-01285-9
  • Singh, J., Ponnaiyan, S., Gieselmann, V., Winter, D. Generation of Antibodies Targeting Cleavable Cross-Linkers. Anal Chem. 2021 Feb 16. doi: 10.1021/acs.analchem.0c04043. Online ahead of print.
  • Mosen, P., Sanner, A., Singh, J., Winter, D. Targeted Quantification of the Lysosomal Proteome in Complex Samples. Proteomes 2021, 9(1), 4; https://doi.org/10.3390/proteomes9010004

2020

  • Akter, F., Ponnaiyan S., Kögler-Mohrbacher, B., Bleibaum, F., Damme, M., Renard, B.Y., Winter, D. Multi cell line analysis of lysosomal proteomes reveals unique features and novel lysosomal proteins. https://doi.org/10.1101/2020.12.21.423747 - PREPRINT
  • Hardt, R., Jordans, S., Winter, D., Gieselmann, V., Wang-Eckhardt, L., Eckhardt, M. Decreased turnover of the CNS myelin protein Opalin in a mouse model of hereditary spastic paraplegia 35. Human Molecular Genetics, ddaa246, https://doi.org/10.1093/hmg/ddaa246 Published: 20 November 2020
  • Contreras, P., Tapia, P., González-Hódar, L., Peluso, I., Soldati, C., Napolitano, G., Matarese, M., Las Heras, M., Valls, C., Martinez, A., Balboa, E., Castro, J., Leal, N., Platt, F., Sobota, A., Winter, D., Klein, A., Medina, D., Ballabio, A.,  Alvarez, A., Zanlungo, S.  c-Abl Inhibition Activates TFEB and Promotes Cellular Clearance in a Lysosomal Disorder. iScience, Volume 23, Issue 11, 20 November 2020, 101691 https://doi.org/10.1016/j.isci.2020.101691
  • Goebel, T., Mausbach, S., Tuermer, A., Eltahir, H., Winter, D., Gieselmann, V., Thelen, M. Proteaphagy in Mammalian Cells Can Function Independent of ATG5/ATG7. Molecular & Cellular Proteomics April 16, 2020, mcp.RA120.001983; https://doi.org/10.1074/mcp.RA120.001983
  • Ponnaiyan, S., Akter, F., Singh, J., Winter, D. Comprehensive Draft of the Mouse Embryonic Fibroblast Lysosomal Proteome by Mass Spectrometry Based Proteomics. Sci Data. 7 (1), 68 2020 Feb 26 DOI: 10.1038/s41597-020-0399-5
  • Erjaee, Z., Shekarforoush, S.S., Hosseinzadeh, S., Dheghani, A., Winter, D. Identification of Antifungal Intracellular Proteins of Endophytic Bacillus pumilus by LC–MS/MS Analysis. Int J Pept Res Ther (2020). https://doi.org/10.1007/s10989-020-10040-8
  • Singh, J., Kaade. E., Muntel, J., Bruderer, R., Reiter, L., Thelen, M., Winter, D. Systematic comparison of strategies for the enrichment of lysosomes by data independent acquisition. J. Proteome Res. 2020, 19, 1, 371-381 DOI: 10.1021/acs.jproteome.9b00580

2019

  • Rehorst, W.A., Thelen, M.P., Nolte, H., Türk, C., Cirak, S., Peterson, J.M., Wong, G.W., Wirth, B., Krüger, M., Winter, D., Kye, M.J. Muscle regulates mTOR dependent axonal local translation in motor neurons via CTRP3 secretion: implications for a neuromuscular disorder, spinal muscular atrophy. Acta Neuropathol Commun. 2019 Oct 15;7(1):154. doi: 10.1186/s40478-019-0806-3.
  • Schoor, C., Brocke‐Ahmadinejad, N., Gieselmann, V., Winter, D., Investigation of Oligodendrocyte Precursor Cell Differentiation by Quantitative Proteomics. PROTEOMICS 2019 Jun 19:e1900057. doi: 10.1002/pmic.201900057.
  • Ahmadi, S., Winter, D., Identification of unexpected protein modifications by mass spectrometry based proteomics. Methods in molecular biology, “Functional Proteomics” (Clifton, N.J.) 2019, 1871: 225-251
  • Khundadze, M., Ribaudo, F., Hussain, A., Rosentreter, J., Nietzsche, S., Thelen, M., Winter, D., Hoffmann, B., Afzal, M.A., Hermann, T., de Heus, C., Piskor, E.M., Kosan, C., Franzka, P., von Kleist, L., Stauber, T., Klumperman, J., Damme, M., Proikas-Cezanne, T., Hübner, C.A. A mouse model for SPG48 reveals a block of autophagic flux upon disruption of adaptor protein complex five. Neurobiology of Disease 2019, July; 127: 419-431.

2018

  • Di Lorenzo, G., Velho, R.V., Winter, D., Thelen, M., Ahmadi, S., Schweizer, M., De Pace, R., Cornils, K., Yorgan, T.A., Grüb, S. and Hermans-Borgmeyer, I., Schinke, T., Müller-Loennies, S., Braulke, T., Pohl, S. Lysosomal proteome and secretome analysis identifies missorted enzymes and their non-degraded substrates in mucolipidosis III mouse cells. Molecular & Cellular Proteomics, August 1, 2018, First published on May 17, 2018, 17 (8) 1612-1626; https://doi.org/10.1074/mcp.RA118.000720
  • Ahmadi, S. and Winter, D. Identification of Poly(ethylene glycol) and Poly(ethylene glycol)-Based Detergents Using Peptide Search Engines. Analytical Chemistry 2018, Jun 5;90(11):6594-6600
  • Course, M.M., Scott, A.I., Schoor, C., Hsieh, C.H., Papakyrikos, A.M., Winter, D., Cowan, T.M. and Wang, X.Phosphorylation of MCAD selectively rescues PINK1 deficiencies in behavior and metabolism. Mol Biol Cell. 2018 May 15;29(10):1219-1227.  doi: 10.1091/mbc.E18-03-0155.    
  • Dehghani, A., Godderz, M. and Winter, D., Tip-Based Fractionation of Batch-Enriched Phosphopeptides Facilitates Easy and Robust Phosphoproteome Analysis. Journal of Proteome Research 17:46-54.
  • Tsai, P.-I., Lin, C.-H., Hsieh, C.-H., Papakyrikos A.M., Kim M.J., Napolioni, V., Schoor, C., Couthouis, J., Wu, R.-M., Wszolek, Z.K., Winter, D., Greicius, M.D., Ross, O.A. and Wang, X. PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista Junctions. Mol Cell. 2018 Mar 1;69(5):744-756.e6.  doi: 10.1016/j.molcel.2018.01.026.
  • Hardt, R.Winter, D., Gieselmann, V. and Eckhardt, M. Identification of progesterone receptor membrane component-1 as an interaction partner and possible regulator of fatty acid 2-hydroxylase. Biochemical Journal, 2018, 475(5):853-871, doi: 10.1042/bcj20170963

2017

  • Thelen, M., Winter, D., Markmann, S., Braulke, T., and Gieselmann, V. (2017) SILAC-based comparative proteomic analysis of lysosomes from mammalian cells using LC-MS/ MS. Methods Mol Biol. 2017;1594:1-18.  doi: 10.1007/978-1-4939-6934-0_1.  
  • Müller, T. and Winter, D. Systematic Evaluation of Protein Reduction and Alkylation Reveals Massive Unspecific Side Effects by Iodine-containing Reagents. Molecular & Cellular Proteomics 16:1173-1187.
  • Peng, B., Weintraub, S.T., Coman, C., Ponnaiyan, S., Sharma, R., Tews, B., Winter, D. and Ahrends, R. A Comprehensive High-Resolution Targeted Workflow for the Deep Profiling of Sphingolipids. Analytical Chemistry 89:12480-12487.

2016

  • Konopka, A., Winter, D., Konopka, W., Busto, M. E. D., Nunez, S., Goenaga-Infante, H., Fisicaro, P., and Lehmann, W. D. (2016) Sec-to-Cys selenoprotein - a novel type of recombinant, full-length selenoprotein standard for quantitative proteomics. Journal of Analytical Atomic Spectrometry 31, 1929-1938
  • Ditgen, D., Anandarajah, E. M., Hansmann, J., Winter, D., Schramm, G., Erttmann, K. D., Liebau, E., and Brattig, N. W. (2016) Multifunctional Thioredoxin-Like Protein from the Gastrointestinal Parasitic Nematodes Strongyloides ratti and Trichuris suis Affects Mucosal Homeostasis. Journal of Parasitology Research 2016, 17
  • Jalaei, J., Fazeli, M., Rajaian, H., Ghalehsoukhteh, S. L., Dehghani, A., and Winter, D. (2016) In vitro antihistamine-releasing activity of a peptide derived from wasp venom of Vespa orientalis. Asian Pacific Journal of Tropical Biomedicine 6, 259-264

2015

  • Winter, D., Dehghani, A., and Steen, H. (2015) Optimization of Cell Lysis and Protein Digestion Protocols for Protein Analysis by LC-MS/MS. Methods in molecular biology (Clifton, N.J.) 1295, 259-273
  • Shahraz, A., Kopatz, J., Mathy, R., Kappler, J., Winter, D., Kapoor, S., Schutza, V., Scheper, T., Gieselmann, V., and Neumann, H. (2015) Anti-inflammatory activity of low molecular weight polysialic acid on human macrophages. Scientific Reports 5

2014

  • Prabakaran, S., Hemberg, M., Chauhan, R., Winter, D., Tweedie-Cullen, R. Y., Dittrich, C., Hong, E., Gunawardena, J., Steen, H., Kreiman, G., and Steen, J. A. (2014) Quantitative profiling of peptides from RNAs classified as noncoding. Nat Commun. 2014 Nov 18;5:5429.  doi: 10.1038/ncomms6429.  

  • Singh, S.*, Winter, D.*, Kirchner, M.*, Chauchan, R.*, Ahmed, S., Uzlu, N., Tzur, A., Steen, J.A., Steen, H., Co-regulation proteomics reveals substrates and mechanisms of APC/C dependent degradation. EMBO J. 2014 Feb 18;33(4):385-99.  doi: 10.1002/embj.201385876.  *shared first authors

2013

  • Eichhorn T., Winter D., Büchele B., Dirdjaja N., Frank M., Lehmann W.D., Mertens R., Krauth-Siegel R.L., Simmet T., Granzin J., Efferth T., Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum. Biochem Pharmacol., 2013, 85, 38-45.

2012

  • Winter, D., Hung, C.W., Jaskolla, T.W., Karas, M., Lehmann, W.D., Enzyme-cleavable Tandem Peptides for Quantitative Studies in Mass Spectrometry-Based Proteomics, Proteomics, 2012, 12, 3470-3474.

  • Renard B.Y., Xu B., Kirchner M., Zickmann F., Winter D., Korten S., Brattig N.W., Tzur A., Hamprecht F.A., Steen H., Overcoming species boundaries in peptide identification with BICEPS. Mol Cell Proteomics, 2012, 11.

  • Singh, S., Winter, D., Bilimoria, P., Bonni, A., Steen, H., Steen, J., FLEXIQinase: A Novel High Resolution, Next Generation Kinase Assay. Nature Methods, 2012, 9, 504-508.
  • Weeraratne S.D., Amani V., Teider N., Pierre-Francois J., Winter D., Kye M.J., Sengupta S., Archer T., Remke M., Bai A.H., Warren P., Pfister S.M., Steen J.A., Pomeroy S.L., Cho Y.J., Pleiotropic effects of miR-183~96~182 converge to regulate cell survival, proliferation and migration in medulloblastoma. Acta Neuropathol. 2012 Apr;123(4):539-552.

2011

  • Wang, X., Winter, D., Ashrafi, G., Schlehe, J., Wong, Y.L., Selkoe, D., Rice, S., Steen, J., Lavoie, M.J., Schwarz, T.L., PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility. Cell 2011, 147, 893-906.
  • Winter, D., Steen, H., Optimization of Cell Lysis and Protein Digestion Protocols for the Analysis of HeLa S3 Cells by LC-MS/MS. PROTEOMICS, 2011, 11, 4726-4730.
  • Seidler, J., Zinn, N., Haaf, E., Boehm, M. E., Winter, D., Schlosser, A., Lehmann, W.D., Metal ion-mobilizing additives for comprehensive detection of femtomole amounts of phosphopeptides by reversed phase LC-MS. Amino Acids 2011, 41, 311-320.

2010

  • Zinn, N., Winter, D., Lehmann, W. D., Recombinant isotope labeled and selenium quantified proteins for absolute protein quantification. Analytical Chemistry 2010, 82, 2334-2340.
  • Winter, D., Seidler, J., Kugelstadt, D., Derrer, B., Kappes, B., Lehmann, W.D., Minimally permutated peptide analogs as internal standards for relative and absolute quantification of peptides and proteins. PROTEOMICS 2010, 10, 1510-1514.
  • Winter, D., Seidler, J., Hahn, B., Lehmann, W. D., Structural and Mechanistic Information on c(1) Ion Formation in Collision-Induced Fragmentation of Peptides. J. Am. Soc. Mass Spectrom. 2010, 21, 1814-1820.

2009

  • Winter, D., Seidler, J., Ziv-Lehrman, S., Shiloh, Y., Lehmann, W. D., Simultaneous Identification and Quantification of Proteins by Differential O-16/O-18 Labeling and UPLC-MS/MS Applied to Mouse Cerebellar Phosphoproteome Following Irradiation. Anticancer Research 2009, 29, 4949-4958.
  • Winter, D., Seidler, J., Ziv, Y., Shiloh, Y., Lehmann, W. D., Citrate Boosts the Performance of Phosphopeptide Analysis by UPLC-ESI-MS/MS. Journal of Proteome Research 2009, 8, 418-424.
  • Winter, D., Pipkorn, R., Lehmann, W. D., Separation of peptide isomers and conformers by ultra performance liquid chromatography. Journal of Separation Science 2009, 32, 1111-1119.
  • Winter, D., Lehmann, W. D., Sequencing of the thirteen structurally isomeric quartets of N-terminal dipeptide motifs in peptides by collision-induced dissociation. PROTEOMICS 2009, 9, 2076-2084.
  • Winter, D., Lehmann, W. D., Individual b(2) ion fragmentation profiles combined with AspN digestion improve N-terminal peptide sequencing. Anal. Bioanal. Chem. 2009, 393, 1587-1591.
  • Winter, D., Kugelstadt, D., Seidler, J., Kappes, B., Lehmann, W. D., Protein phosphorylation influences proteolytic cleavage and kinase substrate properties exemplified by analysis of in vitro phosphorylated Plasmodium falciparum glideosome-associated protein 45 by nano-ultra performance liquid chromatography-tandem mass spectrometry. Analytical Biochemistry 2009, 393, 41-47.
  • Schilling, M., Maiwald, T., Hengl, S., Winter, D., Kreutz, C., Kolch, W., Lehmann, W.D., Timmer, J., Klingmüller, U., Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions. Molecular Systems Biology 2009, 5, 334.
  • Renard, B. Y., Kirchner, M., Monigatti, F., Ivanov, A. R., Rappsilber, J., Winter, D., Steen, J., Hamprecht, F.A., Steen, H., When less can yield more - Computational preprocessing of MS/MS spectra for peptide identification. PROTEOMICS 2009, 9, 4978-4984.
  • Brenner, D., Brechmann, M., Rohling, S., Tapernoux, M., Mock, T., Winter, D., Lehmann, W.D., Kiefer, F., Thome, M., Krammer, P.H., Arnold, R., Phosphorylation of CARMA1 by HPK1 is critical for NF-kappa B activation in T cells. Proc. Natl. Acad. Sci. U. S. A. 2009, 106, 14508-14513.

2008

  • Winter, D., Shiloh, Y., Lehmann, W. D., Phosphopeptide Isomer Analysis by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry. AL On-Line 2008, June 2008, 21-24.

2007

  • Kugelstadt, D., Winter, D., Pluckhahn, K., Lehmann, W. D., Kappes, B., Raf kinase inhibitor protein affects activity of Plasmodium falciparum calcium-dependent protein kinase 1. Mol. Biochem. Parasitol. 2007, 151, 111-117.

 

Patents

  • European Patent EP20080786120: Winter, D., Lehmann, W. D., Method for determining the concentration of a molecule.
  • US Patent US 8,044,345 B2: Winter, D., Lehmann, W. D., Method for determining the concentration of a molecule.
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