Stellenangebote / Job Offers

Im UKB werden pro Jahr etwa 500.000 Patient*innen betreut, es sind ca. 9.000 Mitarbeiter*innen beschäftigt und die Bilanzsumme beträgt 1,6 Mrd. Euro. Neben den über 3.300 Medizin- und Zahnmedizin-Studierenden werden pro Jahr weitere 585 Personen in zahlreichen Gesundheitsberufen ausgebildet. Das UKB steht im Wissenschafts-Ranking sowie in der Focus-Klinikliste auf Platz 1 unter den Universitätsklinika (UK) in NRW und weist den dritthöchsten Case Mix Index (Fallschweregrad) in Deutschland auf. 

The University Hospital Bonn (UKB) is a maximum care hospital with more than 1,300 beds. Our more than 9,000 employees take on tasks in research, teaching and patient care as well as in public health at the highest level. In the science ranking (LOMV) and in the economic result, the UKB is number 1 of the university hospitals in NRW and in 2021 had the third highest case mix index of the university hospitals in Germany.

Am Institut für Biochemie und Molekularbiologie der Medizinischen Fakultät der Universität Bonn sind folgende Stellen zu besetzen
(Kurzbeschreibung; Ausschreibungstexte s. unten):

- Studentische Hilfskraft (m/w/d), ab 1.10.2024 mit dem Schwerpunkt Informatik

- PhD student or Postdoctoral researcher (m/f/d), as soon as possible - AG Becker

- PhD student (m/f/d), as soon as possible - AG den Brave

Studentische Hilfskraft (m/w/d) mit dem Schwerpunkt Informatik, Teilzeitstelle (10 Stunden pro Woche) - ab 1.10.2024

Die Stelle ist zunächst auf 6 Monate befristet, es besteht die Möglichkeit zur Verlängerung.

Ihre Aufgaben:

  • Einrichtung, Konfiguration und Instandhaltung von Endgeräten (PC, Laptop, Tablet)
  • Installation von Software
  • Lösen von IT-Problemen der Mitarbeiter/innen des Instituts
  • Unterstützung bei der Beschaffung von Hardware und Peripheriegeräten
  • Aufnahme, Analyse und Bearbeitung von Benutzeranfragen
  • Einrichten von Benutzer-Accounts, Mailadressen, Uni-IDs, VPN
  • Unterstützung bei der Planung und Implementierung von Bioinformatik-Projekten
  • Etablierung KI-basierter Strukturanalyse von Proteinen

Ihr Profil:

  • Immatrikulation in einem Studiengang mit Bezug zur Informatik im Raum Bonn
  • Gute Englisch- und Deutschkenntnisse
  • Gute zwischenmenschliche Fähigkeiten
  • Gewissenhafter, sorgfältiger Arbeitsstil auf höchstem Qualitätsniveau
  • Zeitliche Flexibilität
  • Technisches Verständnis im Allgemeinen
  • Umfassende Kenntnisse von Windows 10 und MacOS
  • Kenntnisse von Microsoft Office

Wir bieten:

  • Verantwortungsvoll und vielseitig: ein Arbeitsplatz mit großem Gestaltungsspielraum in einem kollegialen Team
  • Sicher in der Zukunft: Entgelt nach TV-L
  • Flexibel für Familien: flexible Arbeitszeitmodelle, Möglichkeit auf einen Platz in der Betriebskindertagesstätte und Angebote für Elternzeitrückkehrer
  • Vorsorgen für später: Betriebliche Altersvorsorge
  • Clever zur Arbeit: Möglichkeit eines zinslosen Darlehens zur Anschaffung eines E-Bikes
  • Bildung nach Maß: Geförderte Fort- und Weiterbildung
  • Start mit System: Strukturierte Einarbeitung
  • Gesund am Arbeitsplatz: Zahlreiche Angebote der Gesundheitsförderung
  • Arbeitgeberleistungen: Vergünstigte Angebote für Mitarbeiter*innen

Wir setzen uns für Diversität und Chancengleichheit ein. Unser Ziel ist es, den Anteil von Frauen in Bereichen, in denen Frauen unterrepräsentiert sind, zu erhöhen und deren Karrieren besonders zu fördern. Wir fordern deshalb einschlägig qualifizierte Frauen nachdrücklich zur Bewerbung auf. Bewerbungen werden in Übereinstimmung mit dem Landesgleichstellungsgesetz behandelt. Die Bewerbung geeigneter Menschen mit nachgewiesener Schwerbehinderung und diesen gleichgestellten Personen ist besonders willkommen.
 
Bei Interesse senden Sie Ihre Bewerbung mit der Angabe ST-6042 inkl. Anschreiben, Lebenslauf und Zeugnissen bitte bis zum 01.10.2024 per Mail an:
 


Herrn Prof. Dr. Thomas Becker
Institut für Biochemie und Molekularbiologie
Medizinische Fakultät der Universität Bonn
Nussallee 11
53115 Bonn
Tel.: 0228-73-2900
Email: thbecker@uni-bonn.de

PhD Student or Postdoctoral researcher (m/f/d), available a full time (38,5 h/week)

The position starts as soon as possible and is for a period of three years, with the possibility of an extension.
Mitochondria fulfil various essential functions for the survival of eukaryotic cells. Their biogenesis and functions depend on the import of more than 1000 different proteins that are produced as precursors on cytosolic ribosomes. Mitochondrial protein import is an essential process for cell survival and defects cause severe neurodegenerative diseases and cardiomyopathy. The translocase of the outer mitochondrial membrane (TOM complex) forms the entry gate for precursor proteins, which are subsequently sorted via dedicated protein machineries into the different mitochondrial subcompartments. Our biochemical and proteomic studies identified partner proteins of protein translocases, linking protein import to organelle-contact sites, protein quality control mechanisms and mitochondrial metabolism (Mårtensson et al., 2019 Nature; Ellenrieder et al., 2019 Mol. Cell). In the frame of the DFG-funded priority program SPP2453, we will investigate molecular mechanisms that control protein transport to mitochondria.
We use highly innovative techniques in biochemistry, molecular and cell biology such as protein-protein-interaction studies coupled with proteomics, activity assays, blue native electrophoresis, cell-free protein synthesis and protein stability assays. We offer a well-equipped workspace in an active international team. The University of Bonn provides an excellent scientific research environment.
The ideal candidate will be a highly motivated, team-oriented graduate with a strong interest in protein biochemistry, molecular and cell biology. Experience with biochemical, cell and molecular biology techniques or proteomics is advantageous. Candidates should hold a diploma or a master’s degree in Biology, Biochemistry, Molecular Medicine, Chemistry or a related subject.
We offer:
  • Responsible and versatile: a job with a lot of creative freedom in a collegial team
  • Secure in the future: fee according to TV-L EG13
  • Flexible for families: flexible working time models, the option of a place in the company day-care center and offers for those returning from parental leave
  • Provision for later: company pension scheme
  • Clever to work: Possibility of an interest-free loan to buy an e-bike
  • Tailor-made education: Subsidized further education and training
  • Systematic start: Structured induction
  • Healthy at work: Numerous health promotion offers, free membership in UKBfit
  • Employer benefits: preferential offers for employees (corporate benefits)
The University of Bonn is committed to diversity and equal opportunity. It is certified as a family-friendly university. It aims to increase the proportion of women in areas where women are under-represented and to promote their careers in particular. It therefore urges women with relevant qualifications to apply. Applications will be handled in accordance with the Landesgleichstellungsgesetz (State Equality Act). Applications from suitable individuals with a certified serious disability and those of equal status are particularly welcome.
 
Applications by email only can be sent until two weeks to thbecker@uni-bonn.de. Please refer to the application number ST-6001.
Herrn Prof. Dr. Thomas Becker
Institute of Biochemistry and Molecular Biology
University of Bonn Medical School
Venusberg-Campus 1
53127 Bonn
Tel.: 0228-73-2900
Email: thbecker@uni-bonn.de

PhD student (m/f/d), part-time position (25,025 h/week)

Impaired protein homeostasis (proteostasis) frequently results in the accumulation of protein aggregates, a hallmark of neurodegenerative diseases. Aggregation is often a consequence of impaired folding, defects in complex assembly or failed sorting of proteins. After synthesis, about two thirds of the proteins have to be transported to different cellular compartments during or after synthesis in the cytosol. Impaired sorting results in cytosolic accumulation of such proteins, causing proteotoxic stress and an induction of the cellular stress response. We study the targeting of proteins to mitochondria and their cytosolic quality control when import fails (Paasch et al., 2018, Journal of Biological Chemistry; Schulte et al., 2023 Nature). Using genetic, cell biological, biochemical and proteomic analysis we observed targeting of mitochondrial proteins into the nucleus, where they are subjected to quality control (den Brave et al., Cell reports 2020). In our group, we monitor the fate of non-imported mitochondrial proteins by analysing their stability, sorting, aggregation and post-translational modification by ubiquitin and ubiquitin-like proteins. In the frame of the DFG-funded priority program SPP2453, we will investigate the role of the nucleus as a central hub in the quality control of mitochondrial proteins.
We use highly innovative techniques in biochemistry, molecular and cell biology. This includes robot based genetic screens combined with fluorescent imaging and protein-protein-interaction studies coupled with proteomics activity assays. We study the functionality and fate of proteins using protein stability, aggregation, disaggregation assays and analyse the state of post-translational modifications with ubiquitin-family proteins. We offer a well-equipped workspace in an active international team. The University of Bonn provides an excellent scientific research environment.
The position starts as soon as possible and is for a period of three years until 31.08.2027 due the project, with the possibility of an extension.
The ideal candidate will be a highly motivated, team-oriented graduate with a strong interest in protein biochemistry, molecular and cell biology. Experience with biochemical, cell and molecular biology techniques, microscopy or proteomics is advantageous. Candidates should hold a diploma or a master’s degree in Biology, Biochemistry, Molecular Medicine, Chemistry or a related subject.

 We offer:

  • The salary will be according to the German salary scale TV-L E13 65%
  • Supportive mentoring and a well-equipped laboratory
  • Responsible and versatile: a job with a lot of creative freedom in a collegial team
  • Secure in the future: fee according to TV-L
  • Flexible for families: flexible working time models, the option of a place in the company day-care center and offers for those returning from parental leave
  • Provision for later: company pension scheme
  • Clever to work: Possibility of an interest-free loan to buy an e-bike
  • Tailor-made education: Subsidized further education and training
  • Systematic start: Structured induction
  • Healthy at work: Numerous health promotion offers, free membership in UKBfit
  • Employer benefits: preferential offers for employees (corporate benefits)
The University of Bonn is committed to diversity and equal opportunity. It is certified as a family-friendly university. It aims to increase the proportion of women in areas where women are under-represented and to promote their careers in particular. It therefore urges women with relevant qualifications to apply. Applications will be handled in accordance with the Landesgleichstellungsgesetz (State Equality Act). Applications from suitable individuals with a certified serious disability and those of equal status are particularly welcome.
Applications by email only can be sent to denbrave@uni-bonn.de. Please refer to the application number ST-6045.

Dr. Fabian den Brave
Institute of Biochemistry and Molecular Biology
University of Bonn Medical School
Venusberg-Campus 1
53127 Bonn
Tel.: 0228-73-54150
Email: denbrave@uni-bonn.de
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