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Sie sind hier: Startseite Forschung PD Dr. M. Eckhardt Publikationen


Publikationen der AG Eckhardt seit 2007

Eckhardt, M., and Wang-Eckhardt, L. (2015): A commercial human protamine-2 antibody used in several studies to detect mouse protamine-2 recognizes mouse transition protein-2 but not protamine-2. Mol. Hum. Reprod. 21:825-831.(Highlighted by the Editor-in-Chief of Mol. Hum. Reprod., Professor Chris Barratt, on the webpage of the European Society of Human Reproduction and Embryology, ESHRE)


Maier, H., Wang-Eckhardt, L., Hartmann, D., Gieselmann, V., and Eckhardt, M. (2015): N-acetylaspartate synthase deficiency corrects the myelin phenotype in a Canavan disease mouse model but does not affect survival time. J. Neurosci. 35:14501-14516. (Cover art on the cover of The Journal of Neuroscience, October 28, 2015, 35(43); Image of the Week at of the Society for Neuroscience, November 9, 2015).


Doerr, J., Böckenhoff, A., Ewald, B., Ladewig, J., Eckhardt, M., Gieselmann, V., Matzner, U., Brüstle, O., and Koch, P. (2015): Arylsulfatase A overexpressing human iPSC-derived neural cells reduce CNS sulfatide storage in a mouse model of metachromatic leukodystrophy. Mol. Ther. 23:1519-1531.


Ebel, P., Imgrund, S., Vom Dorp, K., Hofmann, K., Maier, H., Drake, H., Degen, J., Dörmann, P., Eckhardt, M., Franz, T., and Willecke, K. (2014): Ceramide Synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia. Biochem. J. 461:147-158.


Ebel, P., vom Dorp, K., Petrasch-Parwez, E., Zlomuzica, A., Kinugawa, K., Mariani, J., Minich, D., Ginkel, C., Degen, J., Eckhardt, M., Dere, E., Dörmann, P., and Willecke, K. (2013): Inactivation of ceramide synthase 6 in mice results in an altered sphingolipid metabolism and behavioral abnormalities. J. Biol. Chem. 288:21433-21447.


Lodder-Gadaczek, J., Gieselmann, V., and Eckhardt, M. (2013): Vesicular uptake of N-acetylaspartylglutamate is catalyzed by sialin (SLC17A5). Biochem. J. 454:31-38.


Bakhti, M., Snaidero, N., Schneider, D., Aggarwal, S., Möbius, W., Janshoff, A., Eckhardt, M., Nave, K.A., and Simons, M. (2013): Loss of electrostatic cell-surface repulsion mediates myelin membrane adhesion and compaction in the central nervous system. Proc. Natl. Acad. Sci. USA 110:3143-3148.


Ginkel, C., Hartmann, D., vom Dorp, K., Zlomuzica, A., Farwanah, H., Eckhardt, M., Sandhoff, R., Degen, J., Rabionet, M., Dere, E., Dörmann, P., Sandhoff, K., and Willecke, K. (2012): Ablation of neuronal ceramide synthase 1 in mice decreases ganglioside levels and expression of myelin associated glycoprotein in oligodendrocytes. J. Biol. Chem. 287:41888-41902.


Matthes, F., Stroobants, S., Gerlach, D., Wohlenberg, C., Wessig, C., Fogh, J., Gieselmann, V., Eckhardt, M., D'Hooge, R., and Matzner, U. (2012): Efficacy of enzyme replacement therapy in an aggravated mouse model of metachromatic leukodystrophy declines with age. Hum. Mol. Genet. 21:2599-2609.


Kuronen, M., Hermansson, M., Manninen, O., Zech, I., Talvitie, M., Laitinen, T., Gröhn, O., Somerharju, P., Eckhardt, M., Cooper, J., Lehesjoki, A.-E., Lahtinen, U., and Kopra, O. (2012): Galactolipid deficiency characterizes the early pathogenesis of the neuronal ceroid lipofuscinosis model Cln8mnd: implications to delayed myelination and oligodendrocyte maturation. Neuropathol. Appl. Neurobiol. 38:471-486.


Jungnickel, J.,* Eckhardt, M.,* Haastert, K., Claus, P., Bronzlik, P., Lipokatic-Takacs, E., Maier, H., Gieselmann, V., and Grothe, C. (2012): Schwann cell-derived polysialic acid mediates different effects during peripheral nerve regeneration. Glycobiology 22:107-115. (*joint first authors)


Henseler, D., Turner, J., Eckhardt, M., van der Mark, M., Revsin, Y., Lin, M., Kranz, T., and Meyer, J. (2011): Unusual 5'-regulatory structure and regulation of the murine Mlc1 gene: lack of promoter-specific functional elements. J. Nucleic Acids Investig. 2:70-76 (e11).


Maier, H., Meixner, M., Hartmann, D., Sandhoff, R., Wang-Eckhardt, L., Zöller, I., Gieselmann, V., and Eckhardt, M. (2011): Normal fur development and sebum production depends on fatty acid 2-hydroxylase expression in sebaceous glands. J. Biol. Chem. 286:25922-25934.


Marsching, C., Eckhardt, M., Gröne, H.-J., Sandhoff, R., and Hopf, C. (2011): Imaging of complex sulfatides SM3 and SB1a in mouse kidney using MALDI-TOF/TOF mass spectrometry. Anal. Bioanal. Chem. 401:53-64.


Faldini, E., Stroobants, S., Lüllmann-Rauch, R., Eckhardt, M., Gieselmann, V., Balschun, D., and D’Hooge, R. (2011): Telencephalic histopathology and changes in behavioural and neural plasticity in a murine model for metachromatic leukodystrophy. Behav. Brain Res. 222:309-314.


Lodder-Gadaczek, J., Becker, I., Gieselmann, V., Wang-Eckhardt, L., and Eckhardt, M. (2011): N-acetylaspartylglutamate synthetase-II synthesizes N-acetylaspartyl-glutamylglutamate. J. Biol. Chem. 286:16693-16706.


Meixner, M., Jungnickel, J., Grothe, C., Gieselmann, V., and Eckhardt, M. (2011): Myelination in the absence of UDP-galactose:ceramide galactosyltransferase and fatty acid 2-hydroxylase. BMC Neurosci. 12:22.


Eckhardt, M. (2010): Pathology and current treatment of neurodegenerative sphingolipidoses. Neuromolecular Med. 12:362-382.


Becker, I., Lodder, J., Gieselmann, V., and Eckhardt, M. (2010): Molecular characterization of N-acetylaspartylglutamate synthetase. J. Biol. Chem. 285:29156-29164.


Dick, K.J.,* Eckhardt, M.,* Paisán-Ruiz, C.,* Alkhayat Alshehhi, A., Proukakis, C., Sibtain, N., Maier, H., Sharifi, R., Patton, M.A., Bashir, W., Koul, R., Raeburn, S.A., Gieselmann, V., Houlden, H., and Crosby, A.H. (2010): Mutation of fatty acid 2-hydroxylase underlies a complicated form of hereditary spastic paraplegia (SPG35). Hum. Mutat. 31:E1251-E1260. (*contributed equally)


van Zyl, R., Gieselmann, V., and Eckhardt, M. (2010): Elevated sulfatide levels in neurons causes lethal audiogenic seizures in mice. J. Neurochem. 112:282-295.


Imgrund, S., Hartmann, D., Farwanah, H., Eckhardt, M., Sandhoff, R., Degen, J., Gieselmann, V., Sandhoff, K., and Willecke K. (2009): Adult ceramide synthase 2 (CerS2) deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas. J. Biol. Chem. 284:33549-33560.


Eckhardt, M. (2008): The role and metabolism of sulfatide in the nervous system. Mol. Neurobiol. 37:93-103.


Zöller, I., Meixner, M., Hartmann, D., Büssow, H., Meyer, R., Gieselmann, V., and Eckhardt, M. (2008): Absence of 2-hydroxylated sphingolipids is compatible with normal neural development but causes late-onset axon and myelin sheath degeneration. J. Neurosci. 28:9741-9754.


Stroobants, S., Leroy, T., Eckhardt, M., Aerts, J.-M., Berckmans, D., and D'Hooge, R. (2008): Early signs of neurolipidosis-related behavioural alterations in a murine model of metachromatic leukodystrophy. Behav. Brain Res. 189:306-316.


Becker, I., Wang-Eckhardt, L., Yaghootfam, A., Gieselmann, V., and Eckhardt, M. (2008): Differential expression of (dihydro)ceramide synthases in mouse brain: oligodendrocyte-specific expression of CerS2/Lass2. Histochem. Cell Biol. 129:233-241.


Townson, K., Greenshields, K., Veitch, J., Nicholl, D., Eckhardt, M., Galanina, O., Bovin, N., Samain, E., Antoine, T., Bundle, D., Zhang, P., Chun Ling, C., and Willison, H.J. (2007): Sulfatide binding properties of murine and human anti-ganglioside antibodies. Glycobiology 17:1156-1166.


Ramakrishnan, H., Khalaj-Hedayati, K., Lüllmann-Rauch, R., Wessig, C., Fewou, S.N., Maier, H., Goebel, H.H., Gieselmann, V., and Eckhardt, M. (2007): Increasing sulfatide synthesis in myelin-forming cells of arylsulfatase A-deficient mice causes demyelination and neurological symptoms reminiscent of human metachromatic leukodystrophy. J. Neurosci. 27:9482-9490.


Eckhardt, M., Khalaj-Hedayati, K., Pitsch, J., Lüllmann-Rauch, R., Beck, H., Fewou, S.N., and Gieselmann, V. (2007): Sulfatide storage in neurons causes hyperexcitability and axonal degeneration in a mouse model of metachromatic leukodystrophy. J. Neurosci. 27:9009-9021.


Yaghootfam, A., Sorkalla, T., Häberlein, H., Gieselmann, V., Kappler, J., and Eckhardt, M. (2007): Cerebroside sulfotransferase forms homodimers in living cells. Biochemistry 46:9260-9269.


Fewou, S.N., Ramakrishnan, H., Büssow, H., Gieselmann, V., and Eckhardt, M. (2007): Down-regulation of polysialic acid is required for efficient myelin formation. J. Biol. Chem. 282:16700-16711.