Publikationen

Publikationen der AG Matzner seit 2004

Brain cell type-specific endocytosis of arylsulfatase A identifies limitations of enzyme-based therapies for metachromatic leukodystrophy.

Kaminski D, Yaghootfam C, Matthes F, Reßing A, Gieselmann V, Matzner U. Hum Mol Genet. 2021 Feb 4;29(23):3807-3817. doi: 10.1093/hmg/ddaa277.

Metachromatic leukodystrophy and transplantation: remyelination, no cross-correction.
Wolf NI, Breur M, Plug B, Beerepoot S, Westerveld ASR, van Rappard DF, de Vries SI, Kole MHP, Vanderver A, van der Knaap MS, Lindemans CA, van Hasselt PM, Boelens JJ, Matzner U, Gieselmann V, Bugiani M. Ann Clin Transl Neurol. 2020 Feb;7(2):169-180. doi: 10.1002/acn3.50975. Epub 2020 Jan 22.

Potential of surfactant-coated nanoparticles to improve brain delivery of arylsulfatase A.

Schuster T, Mühlstein A, Yaghootfam C, Maksimenko O, Shipulo E, Gelperina S, Kreuter J, Gieselmann V, Matzner U. J Control Release. 2017 May 10;253:1-10. doi: 10.1016/j.jconrel.2017.02.016. Epub 2017 Feb 16.

Arylsulfatase A Overexpressing Human iPSC-derived Neural Cells Reduce CNS Sulfatide Storage in a Mouse Model of Metachromatic Leukodystrophy.

Doerr J, Böckenhoff A, Ewald B, Ladewig J, Eckhardt M, Gieselmann V, Matzner U, Brüstle O, Koch P. Mol Ther. 2015 Sep;23(9):1519-31. doi: 10.1038/mt.2015.106. Epub 2015 Jun 10.

Enzyme replacement therapy of a novel humanized mouse model of globoid cell leukodystrophy.

Matthes F, Andersson C, Stein A, Eistrup C, Fogh J, Gieselmann V, Wenger DA, Matzner U. Exp Neurol. 2015 Sep;271:36-45. doi: 10.1016/j.expneurol.2015.04.020. Epub 2015 May 6.

Anti-inflammatory Therapy With Simvastatin Improves Neuroinflammation and CNS Function in a Mouse Model of Metachromatic Leukodystrophy.

Stein A, Stroobants S, Gieselmann V, D'Hooge R, Matzner U. Mol Ther. 2015 Jul;23(7):1160-1168. doi: 10.1038/mt.2015.69. Epub 2015 Apr 21.

Comparison of five peptide vectors for improved brain delivery of the lysosomal enzyme arylsulfatase A.

Böckenhoff A, Cramer S, Wölte P, Knieling S, Wohlenberg C, Gieselmann V, Galla HJ, Matzner U. J Neurosci. 2014 Feb 26;34(9):3122-9. doi: 10.1523/JNEUROSCI.4785-13.2014.

Transport of arylsulfatase A across the blood-brain barrier in vitro.

Matthes F, Wölte P, Böckenhoff A, Hüwel S, Schulz M, Hyden P, Fogh J, Gieselmann V, Galla HJ, Matzner U. J Biol Chem. 2011 May 20;286(20):17487-94. doi: 10.1074/jbc.M110.189381. Epub 2011 Mar 28.

Lysosomal di-N-acetylchitobiase-deficient mouse tissues accumulate Man2GlcNAc2 and Man3GlcNAc2.

Persichetti E, Klein K, Paciotti S, Lecointe K, Balducci C, Franken S, Duvet S, Matzner U, Roberti R, Hartmann D, Gieselmann V, Beccari T. Biochim Biophys Acta. 2012 Jul;1822(7):1137-46. doi: 10.1016/j.bbadis.2012.03.005. Epub 2012 Mar 20.

Efficacy of enzyme replacement therapy in an aggravated mouse model of metachromatic leukodystrophy declines with age.

Matthes F, Stroobants S, Gerlach D, Wohlenberg C, Wessig C, Fogh J, Gieselmann V, Eckhardt M, D'Hooge R, Matzner U. Hum Mol Genet. 2012 Jun 1;21(11):2599-609. doi: 10.1093/hmg/dds086. Epub 2012 Mar 2.

Intracerebroventricular enzyme infusion corrects central nervous system pathology and dysfunction in a mouse model of metachromatic leukodystrophy.

Stroobants S, Gerlach D, Matthes F, Hartmann D, Fogh J, Gieselmann V, D'Hooge R, Matzner U. Hum Mol Genet. 2011 Jul 15;20(14):2760-9. doi: 10.1093/hmg/ddr175. Epub 2011 Apr 22.

Site-specific analysis of N-linked oligosaccharides of recombinant lysosomal arylsulfatase A produced in different cell lines.

Schröder S, Matthes F, Hyden P, Andersson C, Fogh J, Müller-Loennies S, Braulke T, Gieselmann V, Matzner U. Glycobiology. 2010 Feb;20(2):248-59. doi: 10.1093/glycob/cwp171. Epub 2009 Oct 28.

Saposin B-dependent reconstitution of arylsulfatase A activity in vitro and in cell culture models of metachromatic leukodystrophy.

Matzner U, Breiden B, Schwarzmann G, Yaghootfam A, Fluharty AL, Hasilik A, Sandhoff K, Gieselmann V. J Biol Chem. 2009 Apr 3;284(14):9372-81. doi: 10.1074/jbc.M809457200. Epub 2009 Feb 18.

Enzyme replacement improves ataxic gait and central nervous system histopathology in a mouse model of metachromatic leukodystrophy.

Matzner U, Lüllmann-Rauch R, Stroobants S, Andersson C, Weigelt C, Eistrup C, Fogh J, D'Hooge R, Gieselmann V. Mol Ther. 2009 Apr;17(4):600-6. doi: 10.1038/mt.2008.305. Epub 2009 Jan 27.

Mannose 6-phosphate receptor-dependent endocytosis of lysosomal enzymes is increased in sulfatide-storing kidney cells.

Klein D, Yaghootfam A, Matzner U, Koch B, Braulke T, Gieselmann V. Biol Chem. 2009 Jan;390(1):41-8. doi: 10.1515/BC.2009.009.

Non-inhibitory antibodies impede lysosomal storage reduction during enzyme replacement therapy of a lysosomal storage disease.

Matzner U, Matthes F, Weigelt C, Andersson C, Eistrup C, Fogh J, Gieselmann V. J Mol Med (Berl). 2008 Apr;86(4):433-42. doi: 10.1007/s00109-008-0309-3. Epub 2008 Mar 18.

Induction of tolerance to human arylsulfatase A in a mouse model of metachromatic leukodystrophy.

Matzner U, Matthes F, Herbst E, Lüllmann-Rauch R, Callaerts-Vegh Z, D'Hooge R, Weigelt C, Eistrup C, Fogh J, Gieselmann V.

Modest phenotypic improvements in ASA-deficient mice with only one UDP-galactose:ceramide-galactosyltransferase gene.

Franken S, Wittke D, Mansson JE, D'Hooge R, De Deyn PP, Lüllmann-Rauch R, Matzner U, Gieselmann V. Lipids Health Dis. 2006 Aug 7;5:21. doi: 10.1186/1476-511X-5-21.

Quantitative genotyping of single-nucleotide polymorphisms by allele-specific oligonucleotide hybridization on DNA microarrays.

Rickert AM, Ballvora A, Matzner U, Klemm M, Gebhardt C. Biotechnol Appl Biochem. 2005 Aug;42(Pt 1):93-6. doi: 10.1042/BA20040177.

Enzyme replacement improves nervous system pathology and function in a mouse model for metachromatic leukodystrophy.

Matzner U, Herbst E, Hedayati KK, Lüllmann-Rauch R, Wessig C, Schröder S, Eistrup C, Möller C, Fogh J, Gieselmann V. Hum Mol Genet. 2005 May 1;14(9):1139-52. doi: 10.1093/hmg/ddi126. Epub 2005 Mar 16.
Gene therapy of metachromatic leukodystrophy.

Matzner U, Gieselmann V. Expert Opin Biol Ther. 2005 Jan;5(1):55-65. doi: 10.1517/14712598.5.1.55.

Matzner, U.(2005) Therapy of lysosomal storage diseases. In Lysosomes, Saftig, P. editor. LandesBioscience, Georgetown (TX), U.S.A; ISBN 1-58706-286-0